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Professor David C.Y. Kwan, Ph.D.
Department of Medicine, Faculty of Health Sciences
McMaster University, Hamilton, Ontario, Canada
Ph.D. (1976) Biol. Chem., U. Penn., Philadelphia, USA
M.Sc. (1971) Physic. Chem., Wilkes College, Pa. USA
B. Sc. (1969) Chemistry, Chu-Hai College, Hong Kong
Canada’s Who’s Who; Names in Hong Kong (China)
Canadian Hypertension Soc. Young Investigator Award (1987)
Ontario Heart Fdn Fellowship Awards (1981-1988)
Canadian Heart & Stroke Fdn. Career Investigator (1989-99)
Excellent Tutor Award, Undergrad. MD program, McMaster (2002)
Assist. Professor (1980); Assoc. Professor (1984); Tenured Professor (1988)
Professor Kwan is a basic research scientist specializing in cardiovascular sciences. He was originally trained as a physical chemists and biological chemists during his graduate studies. Since 1976, his research interest has spanned across the boundaries of molecular pharmacology, cellular physiology and natural product research including Chinese medicine, with an emphasis on cellular regulation of calcium and cell signaling processes. He is a founding member of the Smooth Muscle Research Program of McMaster University. He also helped build the Institute of Cardiovascular Sciences and Medicine at the University of Hong Kong when he was the Chair of Physiology there during 1992-1996. To this date, Prof. Kwan has published nearly 350 full-length papers (excluding abstracts) including 25 book chapters and proceeding papers. He has trained numerous research students and postdoctoral fellows coming from many countries of the world He serves as a member on the Editorial Advisory Board of several international journals. For >2 decades, He serves as a reviewer for manuscripts, international research granting agencies (Canada, US, Singapore, Hong Kong), graduate theses and academic promotions worldwide. He has been honored with Visiting Professorship in 10 top medical universities in China, the University of Hong Kong, the National University of Singapore and the National Defense Medical University and Fu-Jen Catholic University in Taiwan.
Prof. Kwan has practiced problem-based learning (PBL) as a tutor in medical education at McMaster University for nearly two decades. He is an award-winning tutor and a dedicated PBL advocate. He helped introduce PBL to the medical faculty of the University of Hong Kong since 1994 and a hybrid model of PBL curriculum was launched in 1997 there. In 2000, Prof. Kwan also helped the Faculty of Medicine of the National University of Singapore develop a hybrid PBL curriculum. Prof. Kwan remains active in the Asia Pacific region towards promotion of both medical education and research. He is instrumental in advocating PBL for medical education reform in this region spanning from Japan to Singapore. He also served as a PBL advisor/consultant for many medical schools in this region. In 2003, he served as a short-term PBL consultant in the Philippines commissioned by WHO in Manila. In 2004, Prof. Kwan spent 6-month sabbatical leave as a Visiting Professor of Andrew T. Huang Fund for Promotion of Medical Education in Taiwan, where he continues to advocate the benefit of PBL in medical education. He has recently visited the University of Hong Kong again serving as a teaching consultant for the Faculty of Science during the initial phase of its education reform.
Recent representative publications in medical education:
1. Kwan, C.Y. Teaching and learning of Pharmacology in medical school: from Canada to Southeast Asia. J. Med. Educ. 4(1): 110-117, 2000.
2. Kwan, C.Y. A Barnett, J. Ceaser, A. Cunje, P. Gamble, A. Hall and P. Krongold. Learning dynamics in Problem-based Learning (PBL): Perspectives form McMaster medical students. J. Med. Edu. (Taiwan) 4 (2): 1-9, 2000.
3. Kwan, C.Y. Medically related cultural issues can be learned by students and need not be taught by teachers in a course. Academic Medicine, 76:1-3, 2001.
4. Kwan, C.Y. Is PBL a quality approach to education in health sciences? Ann. Acad. Med. Singapore, 30: 341-346, 2001.
5. Kwan C.Y. (tutor), H. Jamal, N. Jha, M. Kapoor, S. Katyal, J. Kelly, F. Khan and N. Muhn (mentor) Problem-based Learning in medicine: the first 12 weeks of tutorial. J. Med. Educ. 5: 372-381, 2001.
6. Kwan, C.Y. A note of caution in conducting PBL tutorials: observations in a medical school that newly adopted a PBL curriculum. J. Med. Educ. 5: 87-93, 2001.
7. Kwan, C.Y. Problem-based learning: properly balanced learning? Trends in Pharmacol Sci., 23:163-164, 2002.
8. Kwan, C.Y. Problem-based learning and teaching of medical pharmacology. Naunyn-Schmiedeberg’s Arch. Pharmacol., 366:10-17, 2002.
9. Kwan CY. Teaching of human physiology as it relates to changes in medical education: An Asian perspective based on the yin-yang principle. J Med Educ 6: 449-460, 2002.
10. Kwan, C.Y. (tutor), T. Griffin, A. Hosein, K. Howell, J. Huber-Okrainexc. Y. Hussain. Students’ perspectives on early clinical exposure during the first twelve weeks of medical education at McMaster university. J. Med. Educ. 7: 3-14, 2003.
11. Kwan, C.Y. So, you will be a PBL tutor in a medical school. J. Med. Educ. 7: 313-322, 2003.
12. Kwan, C.Y. Learning of medical pharmacology via innovation: a personal experience at McMaster and in Asia. Acta Pharmacol Sinica 25: 1186-1194, 2004.
Recent representative publications in biomedical sciences:
1. Grover AK, Samson SE, Robinson S, Kwan CY.. Effects of peroxynitrite on sarcoplasmic reticulum Ca2+-pump in pig coronary artery smooth muscle. Am J Physiol, 284:C294-301, 2003.
2. Grover AK, Kwan CY, Samson SE. Effects of peroxynitrite on sarso/ endoplasmic reticulum Ca2+pump isoforms SERCA2b and SERCA 3a. Am. J. Physiol. (cell physiol) 285: C1537-1543, 2003.
3. Walia M, Samson SE, Schmidt T, Best K, Whittington M, Kwan CY, Grover AK. Peroxynitrite and nitric oxide differ in their effects on pig coronary artery smooth muscle. Am J Physiol 284: C649-657, 2003.
4. Walia M, Samson SE, Schmidt T, Best K, Kwan CY, Grover AK. Effects of peroxynitrite on pig coronary artery smooth muscle. Cell Calcium, 34: 69-74, 2003.
5. Achike FI, Kwan CY. Nitric oxide, human diseases and herbal products that act on NO pathway. Clin Expt Physiol Pharmacol 30: 605-615, 2003.
6. Kwan, CY, Kwan TK, Zhang WB, Sakai Y. In vitro relaxation of vascular smooth muscle by atropine: involvement of K+-channels and endothelium. Naunyn-Schimedeberg’s Arch Pharmacol., 368: 1-9, 2003.
7. Kwan CY, Zhang WB, Deyama T, Nishibe S. Eucommia aqueous extract induces endothelium-dependent relaxation in rat aorta and mesenteric artery. Naunyn-Schmiedeberg’s Arch Pharmacol. 369: 206-211,2004.
8. Zheng WB, Chen CX, Sim SM, Kwan CY. In vitro vasodilator mechanisms of indole alkaloids, rhynchophylline and isorhychophylline, isolated from the hook of Uncaria rhychophylla (Miquel). Naunyn-Schmiedeberg’s Arch Pharmacol 369: 232-238, 2004.
9. Kwan CY, Zhang WB, Sim SM, Deyama T, Nishibe S. Vascular effects of Siberian ginseng (Eleutherococcus senticosus): endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size. Schmiedeberg’s Arch Pharmacol. 369: 473-480, 2004.
10. Younglai EV, Kwan T, Kwan CY, Lobb DK, Foster WG. Dichlorodiphenylchloro-ethylene elevates cytosolic calcium concentrations and oscillations in cultured human granulose cells. Biol Reprod 70: 1693-1700, 2004.
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