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a) Biochemistry and biophysics of metalloenzymes, role of metal ions in enzyme catalysis. Spectroscopic studies of protein structure and confromation.
b) Cellular physiology of smooth muscles: membrane biochemistry and biophysics, ion transport and membrane-associated enzymes.
c) Pharmacology of receptor-ligand interactions and signal transduction mechanisms in smooth muscles.
d) Biochemical basis of vascular membrane changes in the pathophysiology of vascular and nonvascular smooth muscles: e.g., in hypertension, diabetes and shock, and endothelium-vascular muscle interactions.
e) Role of intracellular Ca2+ in excitation-contraction as well as stimulation-secretion coupling; Ca2+ signaling and membrane transduction mechanisms.
f) Pharmacology of natural products including Chinese medicinal herbs with actions on Ca2+ channels, Ca2+-pumps and membrane receptors.
g) Reactive oxygen species and oxidative stress on smooth muscle function
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| My students and research staff | | I have had an international group of students and staff for almost 3 decades at McMaster. |
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| A presentation on vascular effects of snake venom | | Dr. Zhang Wen-Bo (China) and Dr. Debra S.M. Sim (Malaysia) did the work. |
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| Calcium imaging of vascular endothelial cells stimulated with ATP and DDE (environmental pollutant) | | When cytosolic free calcium ions level rises, the fluorescence intensity increases as brightened psudocolor. The calcium ion chelator totally reduced the elevated cytosolic calcium concentration to the resting level. |
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